In Diablo 2: Resurrected, players can run the same boss over and over to find loot. Early in the game, the Black Marsh in Act 1 is home to the Countess, who usually drops runes that can be used to craft gear that allows the player to complete at least Normal difficulty. Find Tal and Eth runes to Buy Diablo 2 Resurrected Runes create invisible runes for body armor.

Shael and Eth went into the shield to create Rhyme Rune with better block chance, 25% boost to all resistances and magic discovery. Leaf is a fantastic rune word for sorceresses. Tir and Ral runes into the staves to greatly improve fire skills and cold resistance. The behavior of the game is divided into zones, most of which have their own waypoints that can be used for fast travel.

However, players must discover and activate the waypoint in the wild before accessing it from the Act's main town. Waypoints are static points that always appear in an area. It differs from town portals, which are user-created portals that deactivate once used or the game exits the main menu. If the player plans to run Countess multiple times, the player will need to find the waypoint in Act 1 Black Swamp.

Health potions are usually plentiful early in the game. Players should find many from downed enemies and chests around the world. Antidote potions can be important late in the Diablo 2 Resurrected Runes game, as some high-level enemies' poison attacks continue until the player runs out of life. Consider these when dealing with your boss. Likewise, be sure to bring some Thawing Potions with you when facing Duriel. So be sure to stock up whenever players visit towns.

The player starts the game without any special gear, and the first item the player should look out for is the belt. Even a basic belt will double the player's available space, which will reduce players moving potions from the pack to the belt hotbar. In addition to this, players should also buy a lot of cheap Diablo 2 Resurrected Items from MMOWTS to boost their power in the game.